Development of inducible epigenetic interference tools

Early Stage Researcher 12
Name: Vacant
Gender: tba.
Country of Birth: tba.
MSc in: tba.

Marie Skłodowska Curie PhD Fellowship in Biotechnology and Bioengineering/Synthetic Biology at the Eidgenössische Technische Hochschule Zürich (ETH-Zürich), Switzerland, in the group of Prof. Martin Fussenegger, at the department of Biosystems Science and Engineering
Project: “Development of inducible epigenetic interference tools”
Supervision: PI Prof. Martin Fussenegger (ETH), EpiPredict co-PI Dr Mats Jirstrand (FCC)
PhD programme: ETH Dept. of Biosystems Science and Engineering (

Key Objectives & Expected Results

Brief overview of this project’s objectives and expected results:


  • To build (light/chemical) inducible gene-specific epigenetic interference tools
  • To characterize time-induced epigenetic interference in resistance-induced clones on pathway activation

Expected Results

  • Insight in the interplay of regulatory feedback loops in epigenetic regulation of resistance induction
  • Insight how resistance-induced ERa related pathways are affected in time through epigenetic interference

Host training: Clone generation, gene circuit behaviour, synthetic devices and modelling

Planned secondment(s): UMCG: Epigenetic editing, UvA: Bioinformatics/modelling, FCC: Data integration/modelling