EpiPredict>Research>Projects>Develop tools for targeted epigenetic DNA methylation interference

Develop tools for targeted epigenetic DNA methylation interference

Early Stage Researcher 9
Name: Mihály Koncz
Gender: Male
Country of Birth: Hungary
MSc in: Environmental engineering studies (Politechnica University, Romania)

Marie Skłodowska Curie PhD Fellowship in Cell/Molecular Biology/Biochemistry at the Magyar Tudományos Akadémia Szegedi Biológiai Kutatóközpontja (MTA-SZBK), this is the Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary

Project: “Develop tools for targeted epigenetic DNA methylation interference”

Supervision: PI Dr Antal Kiss (MTA-SZBK), EpiPredict co-PI Dr Marcel Ruiters (Synvolux)

PhD programme: PhD School of Biology of the Univ. of Szeged (www.bdi.u-szeged.hu),
(www.brc.hu/phd_studies.php)

Key Objectives & Expected Results

Objectives

To develop targetable DNA methylation interference tools
To identify the effect of DNA methylation interference on selected genes in endocrine therapy resistant clones

Expected Results

Achieve experimental strategies suitable for targeted DNA methylation (enzyme variants)
Insight whether DNA methylation interference affects selected resistance genes in endocrine therapy resistant clones

Host training: DNA methylation assays, DNA-protein interactions, mutagenesis/directed evolution tools

Planned secondment(s): UMCG: Epigenetic interference (M23-25), Synvolux: Protein/DNA delivery (M10-11), UNIMIB: metabolic/proteomic profiling (M17)