Mihály Koncz

Develop tools for targeted epigenetic DNA methylation interference

Early Stage Researcher 9
Name: Mihály Koncz
Gender: Male
Country of Birth: Hungary
MSc in: Environmental engineering studies (Politechnica University, Romania)



Marie Skłodowska Curie PhD Fellowship in Cell/Molecular Biology/Biochemistry at the Magyar Tudományos Akadémia Szegedi Biológiai Kutatóközpontja (MTA-SZBK), this is the Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary

Project: “Develop tools for targeted epigenetic DNA methylation interference”

Supervision: PI Dr Antal Kiss (MTA-SZBK), EpiPredict co-PI Dr Marcel Ruiters (Synvolux)

PhD programme: PhD School of Biology of the Univ. of Szeged (www.bdi.u-szeged.hu),

Key Objectives & Expected Results



  • To develop targetable DNA methylation interference tools
  • To identify the effect of DNA methylation interference on selected genes in endocrine therapy resistant clones

Expected Results

  • Achieve experimental strategies suitable for targeted DNA methylation (enzyme variants)
  • Insight whether DNA methylation interference affects selected resistance genes in endocrine therapy resistant clones

Host training: DNA methylation assays, DNA-protein interactions, mutagenesis/directed evolution tools

Planned secondment(s): UMCG: Epigenetic interference (M23-25), Synvolux: Protein/DNA delivery (M10-11), UNIMIB: metabolic/proteomic profiling (M17)