Objectives
- To design, construct and test gene-specific epigenetic interference tools
- To identify the effect of epigenetic interference of selected resistance genes in resistance-induced clones
Expected Results
- Insight whether epigenetic interference affects the epigenetic composition of resistance-induced genes
- Insight which resistance-induced ERa related pathways are affected through epigenetic interference
Host training: Epigenetic Editing, Construct/screen (ZFP, CRISRP), ChIP, Bisulfite-PCR/FACS/qRT-PCR
Planned secondment(s): ETH: Inducible gene rewiring (M17-19), MTZ-SZBK: DNA methylation interference tools (M21), Synvolux: Protein/DNA delivery (M10-11, continuous interaction)