Désirée Goubert

Epigenetic editing tools to gene specifically interfere with epigenetics in resistance pathways

Désirée Goubert MSc


"By editing a gene's environment, we can change its outcome."




Early Stage Researcher 8
Name: Désirée Goubert
Gender: Female
Country of Birth: Belgium
MSc in: Clinical and molecular life sciences (Hasselt University, Belgium)


Marie Skłodowska Curie PhD Fellowship in Cell/Molecular/Medical/Synthetic Biology at the University Medical Center Groningen (UMCG), Groningen, the Netherlands, Department of Pathology and Medical Biology, in the research group of Prof. Marianne Rots.


Project: “Epigenetic editing tools to gene specifically interfere with epigenetics in resistance pathways”

Supervision: PI Prof. Marianne Rots (UMCG), EpiPredict co-PI Dr Marcel Ruiters (Synvolux):

PhD programme: Groningen graduate school programme (www.rug.nl/research/gradschool-science/); Royal Dutch Academy for Sciences-approved UMCG Graduate School (www.rug.nl/research/gradschool-medical-sciences/)

Key Objectives & Expected Results


  • To design, construct and test gene-specific epigenetic interference tools
  • To identify the effect of epigenetic interference of selected resistance genes in resistance-induced clones

Expected Results

  • Insight whether epigenetic interference affects the epigenetic composition of resistance-induced genes
  • Insight which resistance-induced ERa related pathways are affected through epigenetic interference

Host training: Epigenetic Editing, Construct/screen (ZFP, CRISRP), ChIP, Bisulfite-PCR/FACS/qRT-PCR

Planned secondment(s): ETH: Inducible gene rewiring (M17-19), MTZ-SZBK: DNA methylation interference tools (M21), Synvolux: Protein/DNA delivery (M10-11, continuous interaction)