Emre Sofyali

Validate epigenetic resistance specific interference in an in vivo mouse model

Emre Sofyali MSc

Early Stage Researcher 6
Name: Emre Sofyali
Gender: Male
Country of Birth: Turkey
MSc in: Molecular Biology, Genetics and Biotechnology (Istanbul Technical University, Turkey)

Marie Skłodowska Curie in Cellular/Molecular/Medical Biology at the Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany, in the Division of Molecular Genome Analysis of Prof. Wiemann. The group aims to understand the complex molecular mechanisms that regulate signalling networks controlling cancer development, metastasis, and drug response as prerequisite to advance personalized treatment. Visit http://www.dkfz.de/en/mga to learn more about the group

Project: “Validate epigenetic resistance specific interference in an in vivo mouse model”

Supervisors: PI Prof. Wiemann (DKFZ), EpiPredict co-PI Dr Ruiters (Synvolux)

PhD programme: DKFZ Int. Helmholtz Graduate School for Cancer Research (www.dkfz.de/en/phd-program) and Faculty of Biosciences, University Heidelberg, Germany

Key Objectives & Expected Results

Expected Results

  • Insight how epigenetic interference influences endocrine resistance development in vivo (mouse model)
  • Validation of the epigenetic interference experiments performed in resistance-induced clones

Host training: Mouse xenografting, tumour monitoring

Planned secondment(s): Synvolux: Protein/DNA delivery (M9), UMCG: Epigenetic interference (M23-25), UvA: Bioinformatics/modelling (M12)